Abstract
Isotretinoin is a first generation retinoid with pleiotropic effects on keratinocyte
differentiation, proliferation, and activity of sebaceous glands. For years, there
has been intense debate on whether the use of isotretinoin combined with cosmetic
or surgical procedures is safe and potentially more efficient than either therapy
alone. Due to delays in wound healing and keloid formation, conservative recommendations
were not to combine isotretinoin with any plastic surgery or local treatment at 6
to 12 months after discontinuation of the drug. However, there is increasing evidence
that a combination approach is not only safe, but may also provide excellent cosmetic
outcomes in acne scars, sebaceous gland hyperplasia, and thick-skinned patients undergoing
facial plastic surgery. In particular, low-dose regimens of isotretinoin may offer
advantages over standard dosage treatments because of better tolerability and safety
in long-term use adjunct with surgical interventions. In this article, the authors
aim to summarize the current evidence on the use of isotretinoin in facial plastic
surgery and to share their experience from selected patients.
Keywords
isotretinoin - acne - scars - laser - facial plastic surgery
